Analgesia			Rescue medication
Study ID	Treatment	PI or PR	Number with 50% PR	PGE: v good or excellent	Median time to use (h)	Number using
Baird 1980	(1) Codeine 60 mg, n = 30 (2) Zomepirac 50 mg, n = 30 (3) Zomepirac 100 mg, n = 29 (4) APC+codeine 60 mg, n = 29 (5) Placebo, n = 30	TOTPAR 6: (1) 7.0 (5) 5.1	(1) 8/30 (5) 5/30	No data	No data	At 6 h: (1) 25/30 (5) 28/30
Bentley 1987	(1) Codeine 60 mg, n = 21 (2) Paracetamol 1000 mg, n = 41 (3) Paracetamol + codeine 1000/60 mg, n = 41 (4) Placebo, n = 17	TOTPAR 5: (1) 7.8 (4) 4.9	(1) 9/21 (4) 4/17	Not reported	(1) 1.84 (4) 1.44	At 4 h: (1) 15/21 (4) 14/17
Bloomfield 1981	(1) Codeine 60 mg, n = 20 (2) Propiram 50 mg, n = 20 (3) Propiram 100 mg, n = 20 (4) Placebo, n = 20	SPID 6: (1) 39.0 (4) 31.7	(1) 7/20 (4) 2/20	No data	No data	No data
Cooper 1982	(1) Codeine 60 mg, n = 41 (2) Ibuprofen 400 mg, n = 38 (3) Ibuprofen + Codeine 400/60 mg, n = 41 (4) Aspirin 650 mg, n = 38 (5) Aspirin + codeine 650/60 mg, n = 45 (6) Placebo, n = 46	TOTPAR 4: (1) 4.1 (6) 2.7	(1) 9/41 (6) 5/46	No usable data	Mean: (1) 2.64 (6) 2.39	No data
Defoort 1983	(1) Codeine 60 mg, n = 15 (2) Ciramadol 30 mg, n = 13 (3) Ciramadol 60 mg, n = 12 (4) Placebo, n = 14	SPID 6: (1) 22.2 (4) 19.9	(1) 6/13 (4) 8/14	No data	No data	(1) 3/15 (4) 1/14
Desjardins 1984	(1) Codeine 60 mg, n = 40 (2) Aspirin 650 mg, n = 40 (3) Propiram 50 mg, n = 40 (4) Placebo, n = 40	TOTPAR 6: (1) 3.9 (4) 3.23	(1) 4/40 (4) 3/40	No usable data	Mean: (1) 2.1 (4) 2.0	No data
Forbes 1986	(1) Codeine 60 mg, n = 44 (2) Naproxen sodium 550 mg, n = 38 (3) Naproxen sodium + codeine 550/60 mg, n = 38 (4) Aspirin 650 mg, n = 36 (5) Placebo, n = 42	TOTPAR 6: (1) 6.4 (5) 4.1	(1) 10/44 (5) 5/42	No usable data	(1) 2.83 (5) 1.94	At 12 h: (1) 33/44 (5) 36/42
Giglio 1990	(1) Codeine 60 mg, n = 39 (2) Meclofenamate 100 mg, n = 41 (3) Meclofen/codeine 50/30 mg, n = 40 (4) Meclofen/codeine 100/60 mg, n = 40 (5) Placebo, n = 40 196 for efficacy: 37, 41, 39, 39, 39	TOTPAR 6: (1) 5.0 (5) 2.6	(1) 6/37 (5) 1/39	No usable data	Mean: (1) 2.89 (5) 1.80	No data
Herbertson 1986	(1) Codeine 60 mg, n = 39 (2) Meclofenamate 100 mg, n = 41 (3) Meclofenamate 200 mg, n = 40 (4) Placebo, n = 41	TOTPAR 6: (1) 6.9 (4) 5.9	(1) 10/39 (4) 9/41	No usable data	No data	At 6 h: (1) 18/39 (4) 22/42
Hersh 1993	All pts pretreated with placebo (1) Codeine 60 mg, n = 16 (2) Ibuprofen 400 mg,  n = 12 (3) Placebo, n = 16	TOTPAR 6: (1) 7.4 (3) 9.0	(1) 5/16 (3) 6/16	No usable data	Mean: (1) 4.2 (3) 1.5	No data
Honig 1984	(1) Codeine 60 mg, n = 28 (2) Paracetamol 600 mg, n = 28 (3) Paracetamol + codeine 600/60 mg, n = 30 (4) Placebo, n = 30	TOTPAR 6: (1) 7.2 (4) 5.2	(1) 8/28 (4) 5/30	At 6 h: (1) 6/27 (4) 4/30	No data	At 6 h: (1) 13/28 (4) 16/30
Jain 1988	(1) Codeine 60 mg, n = 40 (2) Diflunisal 500 mg, n = 41 (3) Diflunisal + codeine 500/60 mg, n = 40 (4) Placebo, n = 40	TOTPAR 4: (1) 7.3 (4) 5.5	(1) 20/40 (4) 14/40	At 8 h: (1) 12/40 (4) 7/40	No data	At 4 h: (1) 6/40 (4) 11/40
Mehlisch 1984	(1) Codeine 90 mg, n = 27 (2) Ketoprofen 25 mg, n = 24 (3) Ketoprofen 50 mg, n = 27 (4) Ketoprofen 100 mg, n = 27 (5) Placebo, n = 24	TOTPAR 6: (1) 3.8 (5) 1.8	(1) 3/27 (5) 0/24	No usable data	No data	At 6 h: (1) 23/27 (5) 23/24
Moore 1997	Dental: (1) Codeine 60 mg, n = 374 (2) Placebo, n = 373 Other surgery: (1) Codeine 60 mg, n = 275 (2) Placebo, n = 283		Dental (1) 36/374 (2) 28/373 Other (1) 63/275 (2) 35/283	No data	No data	No data
Moore 1998	(1) Codeine 60 mg, n = 33 (2) Aspirin + codeine 650/60 mg, n = 41 (3) Tramadol 50 mg, n = 49 (4) Tramadol 100 mg, n = 49 (5) Placebo, n = 27		included in Moore 1997	No usable data	No usable data	At 6 h: (1) 24/30 (5) 23/27
Sunshine 1983	(1) Codeine 60 mg, n = 40 (2) Propiram fumarate 50 mg, n = 41 (3) Placebo, n = 39	TOTPAR 4: (1) 8.6 (3) 5.3	(1) 24/40 (3) 13/39	No data	No data	At 6 h: (1) 2/40 (3) 9/39
Sunshine 1987	(1) Codeine 60 mg, n = 37 (2) Ibuprofen 400 mg, n = 38 (3)Ibuprofen + codeine 200/30 mg, n= 40 (4) Ibuprofen + codeine 400/60 mg, n = 40 (5) Placebo, n = 40	TOTPAR 4: (1) 7.0 (5) 5.2	(1) 17/37 (2) 13/40	No useable data	No useable data	At 4 h: (1) 8/37 (5) 20/40
Sunshine 1988	(1) Codeine 60 mg, n = 51 (2) Piroxicam 20 mg, n = 50 (3) Placebo, n = 50	TOTPAR 6: (1) 11.8 (3) 9.1	(1) 27/51 (3) 19/50	No data	No usable data	At 6 h: (1) 17/51 (3) 23/50
van Steenberghe 1986	(1) Codeine 60 mg, n = 20 (2) Ciramadol 15 mg, n = 13 (3) Ciramadol 30 mg, n = 15 (4) Ciramadol 60 mg, n = 20 (5) Placebo, n = 15		No usable data	No data	No data	No usable data
Yonkeura 1987	(1) Codeine 60 mg, n = 53 (2) Meclofenamate 100 mg, n = 55 (3) Meclofenamate 200 mg, n = 55 (4) Placebo, n = 52	TOTPAR 6: (1) 16.4 (4) 14.0	(1) 42/53 (4) 34/52	No usable data	No data	At 6 h: (1) 21/53 (4) 30/52