Desjardins 1984.

Methods	Randomised, double blind, 4 parallel groups. Single oral dose Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 30, 60 min, then hourly up to 6 hours
Participants	Surgical removal of impacted teeth, mainly third molars N = 160 M = 77, F = 82 Man age 25 years
Interventions	Codeine 60 mg, n = 40 Aspirin 650 mg, n = 40 Propiram 50 mg, n = 40 Placebo, n = 40
Outcomes	PI: standard 4 point scale PR: standard 5 point scale PGE: standard 5 point scale Time use of rescue medication Adverse events: any, serious Withdrawals
Notes	Oxford Qualtiy Score: R1, DB2, W1. Total = 4 Participants asked to wait "as long as possible" before using rescue medication
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Not described
Allocation concealment?	Low risk	Medication "identified only by numerical code"
Blinding? All outcomes	Low risk	capsules "identical in appearance"