Giglio 1990.

Methods	Randomised, double blind, 5 parallel groups. Single oral dose Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 30, 60 min, then hourly to 6 hours
Participants	Surgical removal of impacted third molars N = 200 (196 analysed for efficacy) M = 35, F = 165 Mean age 23 years
Interventions	Codeine 60 mg, n = 39 Meclofenamate 100 mg, n = 41 Meclofenamate/codeine 50/30 mg, n = 40 Meclofenamate/codeine 100/60 mg, n = 40 Placebo, n = 40 196 for efficacy: 37, 41, 39, 39, 39
Outcomes	PI: standard 4 point scale PR: standard 5 point scale PGE: standard 5 point scale Use of rescue medication Adverse events Withdrawals
Notes	Oxford Qualtiy Score: R1, DB2, W1. Total = 4 Timing for use of rescue medication not given
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Not described
Allocation concealment?	Unclear risk	Not described
Blinding? All outcomes	Low risk	"All study medications were identical in appearance"