Honig 1984.
Methods | Randomised, double blind, 4 parallel groups. Single oral dose Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 30, 60 mins, then hourly to 6 hours |
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Participants | Various elective surgical procedures, including orthopaedic, abdominal and thoracic N = 116 M = 71, F = 45 Mean age 45 years |
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Interventions | Codeine 60 mg, n = 28 Paracetamol 600 mg, n = 28 Paracetamol + codeine 600/60 mg, n = 30 Placebo, n = 30 |
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Outcomes | PI: standard 4 point scale PR: standard 5 point scale PGE: standard 5 point scale Use of rescue medication Adverse events: any, serious Withdrawals |
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Notes | Oxford Qualtiy Score: R1, DB2, W0. Total = 3 | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Adequate sequence generation? | Unclear risk | Not described |
Allocation concealment? | Unclear risk | Not described |
Blinding? All outcomes | Low risk | "Capsules were identical in appearance" |