Mehlisch 1984.

Methods	Randomised, double blind, 5 parallel groups. Single oral dose Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 30, 60 mins, then hourly to 6 hours
Participants	Surgical removal of impacted third molars N = 129 M/F not given Mean age 26 years
Interventions	Codeine 90 mg, n = 27 Ketoprofen 25 mg, n = 24 Ketoprofen 50 mg, n = 27 Ketoprofen 100 mg, n = 27 Placebo, n = 24
Outcomes	PI: standard 4 point scale PR: standard 5 point scale PGE: standard 5 point scale (1 to 5 and reverse order) Use of rescue medication Adverse events
Notes	Oxford Qualtiy Score: R2, DB2, W0. Total = 4
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk	Medication "distributed on the basis of a random code"
Allocation concealment?	Low risk	Medication was in an envelope
Blinding? All outcomes	Low risk	"identical capsules"