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. Author manuscript; available in PMC: 2015 Sep 12.
Published in final edited form as: Eur J Med Chem. 2014 Jul 3;84:135–145. doi: 10.1016/j.ejmech.2014.07.007

Scheme 2.

Scheme 2

Reaction conditions: (a) NaOH/H2O, TEBAC, CHCl3, CH2Cl2, reflux; (b) paraformaldehyde, 2,2-dimethoxyethylamine, cyclohexyl carboxylic acid, CH3OH; (c) methanesulfonic acid, 0 °C then 70 °C; (d) BBr3, CH2Cl2; (e) NaH 60% mineral oil disp., THF, reflux; (f) TFAA, pyridine, THF, 0°C; (g) 3-bromopropan-1-ol, K2CO3, CH3CN, reflux; (h) DBU, CH2Cl2.