FIGURE 5.
Virulence studies. (A) Cortisone acetate treated mice were infected with 2 × 105 conidia of the indicated A. fumigatus strains. As control, a group of mice (n = 5) remained uninfected (inhalation of PBS). Survival was monitored for 14 days. (B) Neutropenic mice were infected with 3 × 104 conidia of the indicated A. fumigatus strains. (C) Fresh larvae of the greater wax moth G. mellonella were infected with 5 × 105 conidia of the wild type and the ΔfhpA/ΔfhpB mutant, respectively. As mock control PBS was used. Survival of larvae was monitored for 5 days.