Table 3.

Risk of infection^* by day 15 after stroke for each C allele of the rs4251961 SNP in IL1RN.

infection by day 15:	any infection N=28		PNA N=9		infection (not PNA) N=20
	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
C allele	0.90 (0.49–1.64)	NS	1.72 (0.78–3.81)	0.18	0.54 (0.24–1.24)	0.15
C allele + NIHSS	0.76 (0.36–1.60)	NS	2.12 (0.70–6.45)	0.19	0.46 (0.19–1.14)	0.09
C allele + NIHSS + race	0.72 (0.34–1.53)	NS	2.02 (0.66–6.18)	NS	0.48 (0.19–1.19)	0.11
C allele + NIHSS + race + CHD	0.57 (0.25–1.31)	0.19	1.87 (0.57–6.08)	NS	0.38 (0.14–1.00)	0.05
C allele + NIHSS + race + CHD + HTN	0.59 (0.25–1.37)	NS	1.83 (0.56–5.97)	NS	0.39 (0.14–1.06)	0.06
C allele + NIHSS + race + CHD + HTN + IL-1ra†	0.50 (0.21–1.22)	0.13	1.60 (0.49–5.22)	NS	0.32 (0.11–0.97)	0.04

^*2 patients were excluded from analyses – 1 was infected at the time of stroke onset and the other died before day 15.

SNP = single nucleotide polymorphism, OR = odds ratio, CI = confidence interval, IL-1ra = interleukin-1 receptor antagonist, NIHSS = National Institutes of Health Stroke Scale, CHD = coronary heart disease, HTN = hypertension, NS = not significant (P≥0.200);

^†indicates the plasma concentration of IL-1ra at 72 hours after stroke onset.