Table 4.
The predictive value of the minor C allele of the IL1RN SNP rs4251961 on good outcome (mRS<2) after stroke. N=the number of patients with a good outcome (total number of patients available for assessment at that time point).
| outcome at: | 30 days N=22 (104) |
90 days N=32 (103) |
180 days N=34 (92) |
365 days N=36 (81) |
||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| C allele | 1.48 (0.57–3.85) | NS | 1.13 (0.49–2.62) | NS | 1.05 (0.45–2.45) | NS | 1.22 (0.51–2.97) | NS |
| C allele + NIHSS | 2.72 (0.85–8.68) | 0.09 | 2.28 (0.71–7.29) | 0.16 | 2.13 (0.63–7.25) | NS | 3.59 (0.88–14.74) | 0.08 |
| C allele + NIHSS + age | 2.78 (0.86–8.99) | 0.09 | 2.31 (0.72–7.45) | 0.16 | 2.14 (0.63–7.27) | NS | 3.62 (0.88–14.83) | 0.07 |
| C allele + NIHSS + age + race | 2.70 (0.82–8.82) | 0.10 | 2.46 (0.74–8.13) | 0.14 | 2.19 (0.63–7.61) | NS | 3.14 (0.73–13.46) | 0.12 |
| C allele + NIHSS + age + race + CHD | 2.16 (0.62–7.46) | NS | 2.12 (0.62–7.23) | NS | 1.66 (0.45–6.04) | NS | 3.00 (0.67–13.37) | 0.15 |
| C allele + NIHSS + age + race + CHD + HTN | 2.49 (0.69–9.02) | 0.17 | 2.50 (0.70–9.00) | 0.16 | 1.86 (0.48–7.13) | NS | 6.52 (1.07–39.83) | 0.04 |
| C allele + NIHSS + age + race + CHD + HTN + infection* | 2.33 (0.63–8.63) | NS | 2.34 (0.62–8.83) | NS | 1.68 (0.43–6.61) | NS | 7.67 (1.02–57.46) | <0.05 |
SNP = single nucleotide polymorphism, mRS = modified Rankin Scale, OR = odds ratio, CI = confidence interval, NIHSS = National Institutes of Health Stroke Scale, CHD = coronary heart disease, HTN = hypertension, NS = not significant (P≥0.200),
*
denotes infection by day 15 after stroke