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. 2014 Mar 21;20(17-18):2412–2421. doi: 10.1089/ten.tea.2013.0473

FIG. 4.

FIG. 4.

Pro-tumoral interleukins activity after drug treatment, which were stimulated by dermal equivalent with melanoma. (A) Interleukin (IL)-6 and (B) IL-8 secretion in human melanoma cell lines SK-Mel-19, SK-Mel-103, and SK-Mel-147 treated with 1.2 μM of Dox (IC50) at 48 h or NT. (C) Conditioned media assessed to identify cells type responsible to IL-6 secretion. (D) Conditioned media assessed to identify cells type responsible to IL-8 secretion. Treatment conditions were melanoma cells seeded on plastic, in monolayer (M); on type I collagen (M+Col); on dermal equivalent (M+Eq); and the dermal equivalent control with no melanoma cells (Eq). ***p<0.001. ND, non detectable.