Summary of results A: Pain-free and headache relief.
| Baseline pain intensity |
Studies | Participants or attacks treated | Treatment (%) | Placebo or comparator (%) | RR (95% CI) | NNT (95% CI) | |
|---|---|---|---|---|---|---|---|
| Pain-free at 2 hours | |||||||
| Paracetamol 1000 mg versus placebo | Moderate/severe | 3 | 717 | 19 | 10 | 1.8 (1.2 to 2.6) | 12 (7.5 to 32) |
| Paracetamol 1000 mg versus placebo | Onset | 1 | 576 | 31 | 19 | - | - |
| Paracetamol 1000 mg versus dihydroergotamine 2mg | Onset | 1 | 576 | 31 | 25 | - | - |
| Headache relief at 1 hour | |||||||
| Paracetamol 1000 mg versus placebo | Moderate/severe | 2 | 635 | 39 | 20 | 2.0 (1.5 to 2.6) | 5.2 (3.8 to 8.1) |
| Headache relief at 2 hours | |||||||
| Paracetamol 1000 mg versus placebo | Moderate/severe | 3 | 717 | 56 | 36 | 1.6 (1.3 to 1.8) | 5.0 (3.7 to 7.7) |
| Paracetamol 1000 mg versus placebo | Onset | 1 | 576 | 38 | 20 | - | - |
| Paracetamol 1000 mg versus dihydroergotamine 2 mg | Onset | 1 | 576 | 28 | 20 | - | - |
| Paracetamol 1000 mg + domperidone 20 mg versus sumatriptan 50 mg | Moderate/severe | 1 | 240 | 36 | 33 | - | - |
| Paracetamol 1000 mg + metoclopramide 10 mg versus sumatriptan 100 mg | Moderate/severe | 2 | 1140 | 39 | 42 | 0.93 (0.81 to 1.1) | Not calculated |