Skip to main content
. Author manuscript; available in PMC: 2014 Sep 11.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Nov 10;(11):CD008040. doi: 10.1002/14651858.CD008040.pub2
Methods R, DB, AC, cross-over
Two attacks treated, each with a single dose of each study medication. Mediaction taken at onset.
Rescue medication (usual) after 3 h if necessary
Participants Migraine (Ad Hoc criteria). Aged 18 to 70 years. Frequency 1 to 6 attacks per month
N = 149 (116 used both treatments)
M 16, F 100
Mean age 45 years
Interventions Paracetamol 1000 mg, n = 116
Tolfenamic acid 400 mg, n = 116
Outcomes Adverse events
Notes Oxford Quality Score: R1, DB2, W1. Total = 4
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear Not described
Allocation concealment? Unclear Not described
Blinding?
All outcomes
Yes “identical sealed packages containing two capsules of each drug”