Methods | R, DB, AC, cross-over Two attacks treated, each with a single dose of each study medication. Mediaction taken at onset. Rescue medication (usual) after 3 h if necessary |
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Participants | Migraine (Ad Hoc criteria). Aged 18 to 70 years. Frequency 1 to 6 attacks per month N = 149 (116 used both treatments) M 16, F 100 Mean age 45 years |
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Interventions | Paracetamol 1000 mg, n = 116 Tolfenamic acid 400 mg, n = 116 |
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Outcomes | Adverse events | |
Notes | Oxford Quality Score: R1, DB2, W1. Total = 4 | |
Risk of bias | ||
Item | Authors’ judgement | Description |
Adequate sequence generation? | Unclear | Not described |
Allocation concealment? | Unclear | Not described |
Blinding? All outcomes |
Yes | “identical sealed packages containing two capsules of each drug” |