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. Author manuscript; available in PMC: 2014 Sep 11.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Nov 10;(11):CD008040. doi: 10.1002/14651858.CD008040.pub2

Comparison 1. Paracetamol 1000 mg versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Pain-free at 2 hours 4 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
 1. 1 Moderate/severe pain 3 717 Risk Ratio (M-H, Fixed, 95% CI) 1.80 [1.24, 2.62]
 1.2 Onset of attack 1 576 Risk Ratio (M-H, Fixed, 95% CI) 1.37 [1.04, 1.80]
2 Headache relief at 1 hour 2 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
 2.1 Moderate/severe pain 2 635 Risk Ratio (M-H, Fixed, 95% CI) 1.97 [1.52, 2.55]
3 Headache relief at 2 hours 4 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
 3.1 Moderate/severe pain 3 717 Risk Ratio (M-H, Fixed, 95% CI) 1.55 [1.32, 1.83]
 3.2 Onset of attack 1 576 Risk Ratio (M-H, Fixed, 95% CI) 1.95 [1.47, 2.57]
4 Relief of nausea at 2 hours 2 536 Risk Ratio (M-H, Fixed, 95% CI) 1.37 [1.17, 1.61]
5 Relief of photophobia at 2 hours 3 985 Risk Ratio (M-H, Fixed, 95% CI) 1.40 [1.19, 1.64]
6 Relief of phonophobia at 2 hours 3 944 Risk Ratio (M-H, Fixed, 95% CI) 1.42 [1.21, 1.67]
7 Any functional disability at 2 hours 3 717 Risk Ratio (M-H, Fixed, 95% CI) 0.87 [0.81, 0.94]
8 Relief of functional disability at 2 hours 2 610 Risk Ratio (M-H, Fixed, 95% CI) 1.76 [1.24, 2.48]
9 Use of rescue medication at 6 h 2 635 Risk Ratio (M-H, Fixed, 95% CI) 0.59 [0.47, 0.74]
10 Any adverse event 4 1293 Risk Ratio (M-H, Fixed, 95% CI) 0.78 [0.64, 0.95]