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. Author manuscript; available in PMC: 2014 Sep 11.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Nov 10;(11):CD008040. doi: 10.1002/14651858.CD008040.pub2
Methods R, DB, PC, parallel-group
Four attacks treated. Medication (2 tablets) taken at onset of attack, repeated after 1 and 4 h if necessary (maximum 6 tablets in 24 h). Rescue medication (aspirin 600 mg) after 4 h if necessary
Participants Common or classical migraine (≥ 2 years). Aged 20-50 years. Frequency 2 to 8 per month. Excluded: prophylactic treatment within 4 weeks
N = 49 (42 completed 4 attacks)
M 16, F 33
Mean age 33 years
Interventions Paracetamol + metoclopramide 2 × 500/5 mg
Placebo
Outcomes Severity and duration of attacks
Adverse events
Withdrawals
Notes Oxford Quality Score: R1, DB2, W1. Total = 4
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear Not described
Allocation concealment? Unclear Not described
Blinding?
All outcomes
Yes “matched placebo”