Methods	R, DB, DD, AC, cross-over Two attacks treated with single doses of each of two study medications. Medication taken when pain was moderate or severe. Rescue medication after 4 h if necessary Severity assessed at 0, 1, 2, 4, 24, 48, 72 h
Participants	Migraine ± aura (diagnostic criteria not reported). Aged 18 to 65 years. Duration of condition > 1 year. Frequency ≥ 2 every 12 weeks. Prophylactic therapy (pizotifen, clonidine, β-blockers, calcium channel blockers) allowed if stable for ≥ 3 months and kept constant N = 161 (120 took both treatments and analysed for efficacy) M 9, F 111 Mean age 43 years
Interventions	Paracetamol + domperidone 1000/20 mg + placebo Sumatriptan 50 mg + placebo
Outcomes	Headache relief at 2 h Presence of nausea and vomiting Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1. Total = 4
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Not described
Allocation concealment?	Unclear	Not described
Blinding? All outcomes	Yes	“matching placebos”