Methods	Multicentre, R, DB, parallel-group Three attacks treated with same medication. Second dose of sumatriptan or placebo paracetamol + domperidone allowed after 2 h if necessary. Rescue medication after 4 hours if necessary
Participants	Migraine ± aura (diagnostic criteria not reported). Aged 20 to 65 years. Duration of condition ≥ 1 year. Frequency ≥ 1 every 8 weeks. Excluded: prophylactic treatment within 2 weeks, IHD, chronic analgesic use for other condition N = 607 M 98, F 509 Mean age 39 years
Interventions	Paracetamol + metoclopramide 1000/10 mg, n = 302 Sumatriptan 100 mg, n = 305
Outcomes	Headache relief at 2 h 24 h sustained relief Relief of nausea, vomiting, photophobia/phonophobia Use of rescue medication Adverse events Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1. Total = 5
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	Computer-generated
Allocation concealment?	Yes	Investigators provided with a sealed envelope for each patient - to be returned unopened at the end of the trial, or patient discontinued from trial
Blinding? All outcomes	Yes	Each active treatment had a matched placebo tablet (triple dummy)