Methods	Multicentre, R, DB, PC, parallel-group Single attack treated with a single dose of study medication. Medication taken when pain was moderate or severe. Rescue medication after 2 h if necessary Assessments at 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6 h
Participants	Migraine ± aura (IHS 1988). Aged ≥ 18 years. Frequency 0.5 to 6 per month. Untreated severity ≥ moderate. Excluded: require bedrest for >50%, or vomiting with >2 0% of attacks N = 289 M 58, F 231 Mean age 37 years 15% with aura
Interventions	Paracetamol 1000 mg, n = 147 Placebo, n = 142
Outcomes	Pain-free at 2 h Headache relief at 1 h and 2 h Relief of nausea, photophobia, phonophobia, functional disability Use of rescue medication Adverse events Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1. Total = 5
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	“computer-generated randomization schedule”
Allocation concealment?	Yes	“all information kept in a blinded form until after database was locked”
Blinding? All outcomes	Yes	“identical appearing placebo tablets”