Methods	Multicentre, randomised, double-blind (double-dummy), placebo-controlled, parallel-group. Single oral dose Medication taken when migraine of moderate or severe intensity Assessments at 0, 0.25, 0.5, 0.75, 1, 1.5, 2, 3, and 4 hours If pain not controlled, participants asked to wait 2 hours before taking rescue medication (of participant’s choice)
Participants	Migraine with and without aura (IHS 1988). History: attack at least once every 2 months during past year. Untreated attacks ≥ moderate severity N = 1559 M 306, F 1249 Mean age 38 years History of aura: 21%
Interventions	Ibuprofen 2 × 200 mg, n = 669 Paracetamol + aspirin + caffeine 2 × 250/250/65 mg, n = 669 Placebo, n = 221
Outcomes	Pain-free at 2 hours Presence of nausea, vomiting, photophobia, phonophobia Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1. Total = 4
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Not described
Allocation concealment?	Unclear	Not described
Blinding? All outcomes	Yes	Double-dummy method