Methods	Randomised, double-blind, placebo-controlled, parallel-group. Single oral dose/attack (≥ 2 attacks treated) Medication taken when migraine of moderate or severe intensity Assessments at 0, 2, and 24 hours. If moderate or severe headache persisted after 2 hours, rescue medication allowed (sumatriptan 100 mg or piroxicam 20 mg)
Participants	Migraine with and without aura (IHS 1988). History: at least 12 month hx of migraine with/without aura, no more than 6 attacks/month. Untreated attacks ≥ moderate severity Excluded participants with headaches usually needing bedrest, or ≥ 20% accompanied by vomiting N = 124 (101 analysed) M 18, F 83 Mean age 32 years History of aura: not reported
Interventions	Ibuprofen 400 mg, n = 35 Rofecoxib 25 mg, n = 33 Placebo, n = 33
Outcomes	Headache relief at 2 hours 24 hour sustained relief Use of rescue medication Adverse events Withdrawals
Notes	Oxford Quality Score: R2, DB1, W1. Total 4 Note exclusions >10% lost to follow-up Note: Headache relief not specifically defined
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	“random number tables”
Allocation concealment?	Unclear	Randomisation done by one investigator and responses evaluated by the other, but no details about method of concealment
Blinding? All outcomes	Unclear	Tablets had identical packets, but were not identical in appearance