Comparison 1. IDS vs chemotherapy only.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall survival	3	781	Hazard Ratio (Random, 95% CI)	0.80 [0.61, 1.06]
1.1 General Surgeons or less extensive primary surgery	2	357	Hazard Ratio (Random, 95% CI)	0.68 [0.53, 0.87]
1.2 Gynaecologic oncologists	1	424	Hazard Ratio (Random, 95% CI)	0.99 [0.79, 1.24]
2 Progression-free survival	2	702	Hazard Ratio (Random, 95% CI)	0.88 [0.57, 1.33]
3 Toxic reactions to chemotherapy	2	357	Risk Ratio (M-H, Fixed, 95% CI)	1.19 [0.53, 2.66]
4 Peripheral neuropathy of grade 2 or higher	1		Risk Ratio (IV, Random, 95% CI)	Subtotals only
5 Grade 3 or 4 gastrointestinal adverse events	1		Risk Ratio (IV, Random, 95% CI)	Subtotals only
6 Grade 4 pulmonary adverse events	1		Risk Ratio (IV, Random, 95% CI)	Subtotals only
7 Grade 4 cardiovascular adverse events	1		Risk Ratio (IV, Random, 95% CI)	Subtotals only