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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Cancer Res. 2014 Apr 22;74(11):3137–3145. doi: 10.1158/0008-5472.CAN-13-3634

Table 1.

Plasma pharmacokinetic parameters of paclitaxel (10 mg/kg) in mice using different formulations.

Solubilizer Mouse
genotype		 AUC
(µg×h/ml)		 CL
(L/h/kg)		 T1/2
(h)		 Cmax
(µg/ml)
None Oatp1b2(−/−) 8.51 ± 4.32 1.36 ± 0.493 1.64 ± 0.668 9.37 ± 3.46
None Wildtype 3.44 ± 0.394 2.38 ± 1.26 1.70 ± 0.427 4.61 ± 0.608
PS80 Oatp1b2(−/−) 6.93 ± 0.832 1.26 ± 0.454 1.06 ± 0.265 14.0 ± 3.12
PS80 Wildtype 4.83 ± 0.761 1.94 ± 0.479 1.07 ± 0.230 12.4 ± 3.53
CrEL Oatp1b2(−/−) 25.6 ± 5.23 0.406 ± 0.0962 1.39 ± 0.294 36.9 ± 10.9
CrEL Wildtype 18.8 ± 4.90 0.565 ± 0.174 1.30 ± 0.365 35.8 ± 8.60

Abbreviations: AUC, area under the curve; CL, systemic clearance; T1/2, half life of the terminal phase; Cmax, peak plasma concentration