FIG. 2.
Fibroblast growth factor-2 (FGF-2) facilitates retrograde transport of descending pathways. (A–F) Fluorescence photomicrographs of the sensory motor area of the cerebral cortex (A, C, and E), and red nucleus (B, D, and F), from the sham-operated (A and B), vehicle-treated (C and D), and FGF-2-treated (E and F) groups. Note that a small number of fluorogold (FG)-labeled neurons was observed in the FGF-2-treated animals. (G) Intensity of fluorescence of the FG extracted from the sensory motor area. The intensity in the FGF-2-treated group (n=4) was significantly higher than that of the vehicle-treated group (n=4). The mean value of the sham-operated group (n=3) is expressed as 1.0 (*p<0.05, ***p<0.001 versus the vehicle-treated group; scale bar=50 μm).