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. 2014 Sep 15;31(18):1584–1598. doi: 10.1089/neu.2009.1108

FIG. 7.

FIG. 7.

FGF-2-induced fibronectin-positive cells (FIFs) promote neurite extension through cell-cell interactions and secreted diffusible factors. (A–C) A typical pattern of cortical neurons cultured for 2 days on the monolayer sheet of meninges-derived fibronectin-positive cells (……MDFs) (A) or FIFs (B), and stained for βIII-tubulin antigen. The percentages of neurons with neurites longer than 150 μm are shown (C). (D–F) A typical pattern of cortical neurons cultured for 2 days in medium conditioned by MDFs (D) or FIFs (E), and stained as described above, with the percentage of neurons having neurites longer than 150 μm also shown (F). Note that the percentages were significantly higher when the neurons were cultured on the FIF monolayers or in the medium conditioned by FIFs (*p<0.05, **p<0.01 for difference between the bracketed values; scale bar=50 μm; FGF-2, fibroblast growth factor-2).