Table 4. Half-Lives of Tested Compounds in Liver Microsomes of Different Species.
T1/2 (min) |
|||
---|---|---|---|
compds | human | mouse | rat |
4 | 50.7 ± 1.2 | 53.5 ± 2.4 | 72.3 ± 4.6 |
7 | 45.3 ± 2.0 | 19.7 ± 0.7 | 30.4 ± 1.9 |
15 | 7.8 ± 0.3 | 4.0 ± 0.3 | 9.7 ± 0.4 |
18 | 110.0 ± 5.5 | 123.0 ± 7.7 | 225.0 ± 12.6 |
SMART 10(15) | 17 | ≪5 | 31 |