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. 2014 Aug 14;57(17):7355–7366. doi: 10.1021/jm500764v

Table 4. Half-Lives of Tested Compounds in Liver Microsomes of Different Species.

  T1/2 (min)
compds human mouse rat
4 50.7 ± 1.2 53.5 ± 2.4 72.3 ± 4.6
7 45.3 ± 2.0 19.7 ± 0.7 30.4 ± 1.9
15 7.8 ± 0.3 4.0 ± 0.3 9.7 ± 0.4
18 110.0 ± 5.5 123.0 ± 7.7 225.0 ± 12.6
SMART 10(15) 17 ≪5 31