Table 6.
Joint association of natural folate and intake of vitamin B6, B12, methionine, and alcohol intake with risk of breast cancer among premenopausal AA women in the WCHS
| Other nutrients (median intake) | Natural folate from food (median), mcg/day | |||
|---|---|---|---|---|
| Low (<230.6) | High (≥230.6) | |||
| OR1 | 95% CI2 | OR1 | 95% CI2 | |
| Vitamin B6, mg/day | ||||
| Low (<1.63) | 1.00 | 0.69 | 0.39–1.24 | |
| High (≥1.63) | 0.91 | 0.54–1.55 | 0.66 | 0.41–1.06 |
| p for interaction | 0.90 | |||
| Vitamin B12, mcg/day | ||||
| Low (<4.93) | 1.00 | 0.80 | 0.47–1.60 | |
| High (≥4.93) | 0.91 | 0.58–1.43 | 0.60 | 0.37–0.96 |
| p for interaction | 0.58 | |||
| Methionine, g/day | ||||
| Low (<1.47) | 1.00 | 0.70 | 0.41–1.20 | |
| High (≥1.47) | 0.56 | 0.34–0.92 | 0.42 | 0.25–0.72 |
| p for interaction | 0.82 | |||
| Alcohol intake, g/week | ||||
| Low (<15) | 1.00 | 0.70 | 0.47–1.04 | |
| High (≥15) | 1.54 | 0.93–2.54 | 1.11 | 0.62–1.99 |
| p for interaction | 0.92 | |||
Abbreviations: OR, Odds ratio; 95% CI, 95% confidence interval.
1,2
Models are adjusted for age, ethnicity, country of origin, education, BMI, age at menarche, parity, age at first birth, breastfeeding status, family history of breast cancer, OC use, history of benign breast disease, HRT use, smoking status, alcohol consumption (when not stratified by this variable), and total energy intake.