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. Author manuscript; available in PMC: 2015 Apr 25.
Published in final edited form as: Circ Res. 2014 Apr 25;114(9):1362–1365. doi: 10.1161/CIRCRESAHA.114.303786

Figure 1. Schematic diagram of miR-499 binding to Sox6 mRNA.

Figure 1

An M-fold structure of Sox6 3′UTR is shown with miR-499 binding sites framed in red. These binding domains are enlarged as insets and shown in configurations less favorable (closed) and more favorable (open) for miR-499 seed sequence binding; probability of the more open structure is reported for each as Po. miR-499 is depicted on the open Sox6 configuration in green, with seed sequence in black; RNAhybrid duplex structure and minimum hybridization (binding) energy (BE) is given for each interaction. RNA mass/abundance values determined from publically available adult mouse heart RNA sequencing data are shown as reads/10 million reads.