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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Stem Cells. 2014 Feb;32(2):487–499. doi: 10.1002/stem.1534

Figure 6. SDF1 regulates CK1α levels by proteasomal and transcriptional mechanisms.

Figure 6

A) Proteasomal degradation was necessary for decreased CK1α as the proteasomal inhibitor, Lactacystin (10 μmol/L), blocked SDF-dependent β-catenin whereas the lysosomal inhibitor, E64C (10 μmol/L), did not. C) β-Catenin was ubiquitinated, however, CK1α was not. D) CSPC SDF1 treatment, 25 nM for 1 and 6 hours, decreased CK1α mRNA levels. Values are the mean ± SE, n=3. * p<0.05 vs Veh.