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. 2014 Jul 8;5(4):e01390-14. doi: 10.1128/mBio.01390-14

FIG 6 .

FIG 6 

Proinflammatory cytokine production by Mucor and other pathogenic fungi. The R7B M. circinelloides f. lusitanicus strain induced IL-8 and MIP-1α from THP-1 cells; however, two M. circinelloides f. circinelloides strains (Mucho and 1006PhL) did not, indicating that different host responses to M. circinelloides f. lusitanicus and M. circinelloides f. circinelloides might contribute to the different virulence outcomes in mammalian hosts. The R. delemar isolate RA99-880, which is also a mucoralean fungus and is virulent in mammalian hosts, had results similar to those for the two M. circinelloides f. circinelloides strains. A. fumigatus induced both IL-8 and MIP-1α, but C. albicans only induced MIP-1α, indicating that these pathogens result in host-pathogen interactions that are distinguishable from those of the mucoralean fungi.