Table 2. Binding kinetics for sdAbs targeting the L1 antigen^*.

sdAb	ka (1/Ms)	kd (1/s)	KD (M)
L1-C5	7.2×106 (1.2×106)	3.2×10−2 (3.9×10−3)	4.0×10−9 (2.1×10−10)
L1-E2	6.5×106 (1.6×106)	4.5×10−3 (1.0×10−3)	7.0×10−10 (2.4×10−11)
L1-H2	1.2×106 (1.5×105)	2.1×10−3 (1.7×10−4)	1.8×10−9 (9.0×10−11)
L1-E6	3.9×105 (3.2×104)	1.0×10−3 (3.0×10−5)	2.6×10−9 (1.2×10−10)
L1-H7	5.6×105 (4.3×104)	8.7×10−4 (8.4×10−5)	1.5×10−9 (3.8×10−11)
L1-G2	5.3×105 (3.8×104)	1.0×10−3 (5.4×10−5)	1.9×10−9 (2.0×10−10)
L1-G2+	2.1×106 (5.0×105)	2.1×10−3 (2.8×10−4)	1.0×10−9 (1.3×10−10)

* From binding to at least 3 L1-coated spots, reported as average (standard deviation).