Figure 9. Isoprenoid dependence of simvastatin effects on basal function and the response to β2-AR stimulation.

Myocytes were cultured with simvastatin in the presence of farnesyl pyrophosphate (FPP), and/or geranylgeranyl pyrophosphate (GGPP). A. Basal shortening (as a % of resting cell length). B. % change in shortening in response to β2-AR stimulation with 100 nM zinterol plus 10 nM CGP20712A. n = 32–38 myocytes from 7 hearts * P<0.05, 1-way ANOVA.