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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Nat Immunol. 2014 Mar 30;15(5):423–430. doi: 10.1038/ni.2865

Figure 6. Myeloid cell IL-6 signaling limits LPS-endotoxemia.

Figure 6

(a) qRT-PCR analyses of control (Ctrl) and Il6ra−/− BMDM that were left untreated or stimulated with IL-6 (12 hours) and subsequently exposed to bacterial lipopolysaccharides (LPS) alone or LPS + IL-6 for an additional 24 hours (n=6 vs 6; *p≤0.05 vs LPS + IL-6 stimulated Ctrl; **p≤0.05, ***p≤0.01; Data are expressed as % of LPS stimulated Ctrl). (b) Body weight loss of Ctrl and Il6raΔmyel mice 24 hours after exposure to 1mg/kg LPS (n=7 vs 8; *p≤0.05). (c) Food intake of Ctrl and Il6raΔmyel mice before (basal) and 24 hours after exposure to LPS (n=7 vs 8; *p≤0.01). (d) Respiratory exchange ratio (RER) of Ctrl and Il6raΔmyel mice before (basal) and 24 hours after exposure 1mg/kg LPS (n=7 vs 8; *p≤0.01). (e) Cytokine concentration in circulation of Ctrl and Il6raΔmyel mice 6 hours after exposure to 1mg/kg LPS (n=7 vs 7; **p≤0.01, p=0.06 for IL-4). (f) qRT-PCR analyses of liver and WAT from Ctrl and Il6raΔmyel mice 48 hours after exposure to 1mg/kg LPS (n=7 vs 8; *p≤0.05; Data are expressed as % of Ctrl). (Values are expressed as mean ± sem).