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. 2014 Sep 11;9(9):e107493. doi: 10.1371/journal.pone.0107493

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© 2014 Bogren et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Hydrophilic metabolic profiles for naïve summer euthermic and winter IBA-AGS tended to form distinct clusters separate from each other and the naïve rats. However, there was no statistically significant discrimination between the classes (R² = 1.00, Q² = 0.79, permutation p = 0.70) B: I/R injury–prone rats displayed different hydrophilic metabolic profiles before and three hours after hemorrhagic shock (R² = 0.95, Q² = 0.79, permutation p<0.01.). No such clustering was evident for the AGS in either hibernation season. PLS-DA analysis of ¹H^–NMR of naïve plasma samples (A) or samples from before and after hemorrhagic shock (B).