Methods	Quasi-randomised trial. Women allocated to different groups on alternate days. Treatment group on even number days and placebo on odd number days
Participants	59 women presenting with breast engorgement on 3rd and 5th day post- delivery with pain and tenderness
Interventions	Women in treatment group were given 2 tablets of protease complex 4 times on day 1 after each meal and before bed time and on second and third day they were given 1 tablet 4 times a day and the placebo group were given placebo
Outcomes	Swelling; pain; maternal opinion of treatment.
Notes	It was not clear that all women were breastfeeding.
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	No	Quasi randomisation, allocation by day of the week.
Allocation concealment?	No	Group allocation could be anticipated in advance.
Blinding? Women	Yes	Placebo controlled trial.
Blinding? Clinical staff	Yes	Placebo controlled trial.
Blinding? Outcome assessors	Yes	2 outcome assessors were recording the change of swelling and pain and were not informed as to which participant belonged to which group
Free of other bias?	Yes