Methods	RCT, DB single oral dose and multiple oral dose, 4 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, and 90 mins, then at 2, 3, 4, 5, 6, 7, 8 h
Participants	Impacted third molar extraction Mean age 23 years N = 272 M = 100, F = 172
Interventions	Celecoxib 200 mg, n = 91 Rofecoxib 50 mg, n = 90 Ibuprofen 400 mg, n = 46 Placebo, n = 45
Outcomes	PI: std 4-point scale PR: std 5-point scale PGE: std 5-point scale Time to use of rescue medication Number of participants using rescue medication
Notes	Oxford Quality Score: R2, DB2, W1 Participants asked to refrain from rescue medication for 1.5 h
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	“computer-generated allocation schedule”
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Low risk	Double-dummy method, using marketed tablet or capsule formulations or matching placebos
Incomplete outcome data (attrition bias) All outcomes	Low risk	Participants accounted for; analysis appropriate for relevant time interval
Other bias	High risk	Small treatment group size (90, 91 coxib, 45,46 ibuprofen, and placebo participants)