Methods	RCT, DB single oral dose, 6 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, and 90 mins, then at 2, 3, 4, 5, 6, 7, 8, 10, 12, and 24 h
Participants	Impacted third molar extraction Mean age 22 years N = 304 M = 111, F = 193
Interventions	Celecoxib 400 mg, n = 51 Placebo, n = 52 CS-706 also tested at 10, 50, 100, 200 mg
Outcomes	PI: std 4-point scale PR: std 5-point scale PGE: std 5-point scale Time to use of rescue medication Number of participants using rescue medication
Notes	Oxford Quality Score: R1, DB2, W1 Participants asked to refrain from rescue medication for 1.5 h
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Low risk	Investigator, all study staff and related personnel were unaware of treatment assignment
Blinding (performance bias and detection bias) All outcomes	Low risk	Double-dummy method. Matching tablets for CS-706 and corresponding placebo. Celecoxib and corresponding placebo capsules differed in markings, so participant blindfolded and treatment administered by a third party
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Participants accounted for; analysis appropriate for relevant time interval
Other bias	Unclear risk	Small treatment group size (50 to 51 participants)