Analgesia			Rescue medication
Study ID	Treatment	PI or PR	Number with 50% PR	PGE: very good or excellent	Median time to use (hr)	Number using
Malmstrom 1999	cele 200 mg, n = 91 rofe 50 mg, n = 90 ibu 400 mg,n = 46 placebo, n = 45	TOTPAR 6: (1)9.55 (4)3.07	(1)38/91> (4)2/45	At 8 hrs: (1)26/91 (4)3/45	(1)5.1 (4)1.5	In 24 hrs: (1)71/91 (4)41/45
Gimbel 2001	cele 200 mg, n = 141 hydrocod/paracet 10/1000 mg, n = 136 placebo, n = 141	SPID 6: (1)4.38 (3)2.51	(1)55/141 (3)30/141	No data	(1)> 8 (3)3.9	At 8 hrs: (1)62/141 (3)90/141
Malmstrom 2002	cele 400 mg, n = 151 cele 200 mg, n = 90 rofe 50 mg, n = 150 ibu 400 mg, n = 45 placebo, n = 45	TOTPAR 6: (1)10.98 (2)8.4 (5)1.04	(1)74/151 (2)32/90 (5)0/45	At 8 hrs: (1)62/151 (2)31/90 (5)1/45 Pts did not report - assume poor response	(1)10.6 (2)6.8 (5)1.6	At 24 hrs: (1)99/151 (2)62/90 (5)44/45
Kellstein 2004	cele 200 mg, n = 101 lumira 400 mg, n = 101 rofe 50 mg, n = 102 placebo, n = 51	TOTPAR 6: (1)6.13 (4)1.4	(1)23/101 (4)0/51	No usable data	(1)2.0 (4)1.3	14.9% of whole group
Moberly 2007	cele 400 mg, n= 51 placebo, n = 52 Also tested: CS-706 at 10, 50, 100, 200 mg	TOTPAR 4: (1)7.2 (2)2.4	(1)25/51 (2)4/51	At 24 hrs: (1)49% (2)14%	(1)> 12 (2)1.67	At 6 hrs: (1)12/51 (2)41/51
Doyle 2002	cele 200 mg, n = 74 ibu liquigel 400 mg, n = 74 placebo, n = 26	No usable data	No data	No usable data	(1)> 12 (3)2.0	At 12 hrs: (1)30/74 (3)21/26
Cheung 2007	cele 400 mg, n = 57 ibu 400 mg, n = 57 placebo, n = 57	TOTPAR 6: (1)13.4 (3)3.7	(1)36/57 (3)5/57	No data	(1)> 24 (3)1.85	At 24 hrs: (1)26/57 (3)49/57
Fricke 2008	cele 400 mg, n = 156 lumira 400 mg, n = 156 placebo, n = 52	TOTPAR 6: (1)7.78 (3)1.76	(1)49/156 (3)0/52	No usable data	(1)3.8 (3)1.3	At 24 hrs: (1)103/156 (3)47/52

cele - celecoxib; CS-706 - experimental compound; hydrocod/paracet - hydrocodone/paracetamol; ibu - ibuprofen; lumira - lumira-coxib; pts - participants; rofe - rofecoxib