Methods	RCT, DB single oral dose, 3 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, 90 mins then hourly up to 12 h, and at 16 and 24 h
Participants	Impacted third molar extraction Mean age 22 years N = 171 M = 77, F = 94
Interventions	Celecoxib 400 mg, n = 57 Ibuprofen 400 mg, n = 57 Placebo, n = 57
Outcomes	PI: std 4-point scale PR: std 5-point scale Time to use of rescue medication Number of participants using rescue medication Number of participants reporting any adverse event and serious adverse events Number of participants withdrawing due to adverse event
Notes	Oxford Quality Score: R2, DB2, W1 Participants asked to refrain from rescue medication for 1 h
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	“computer-generated randomization schedule, prepared before the start of the study”
Allocation concealment (selection bias)	Low risk	Medication supplied in patient-specific carton. Identity of assignment contained in concealed section of label, which was removed at dispensing, and attached to patient case report form
Blinding (performance bias and detection bias) All outcomes	Low risk	Double-blind method. Placebo capsules or tablets identical in number and appearance to active treatments
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants accounted for; analysis appropriate for relevant time interval
Other bias	Unclear risk	Small treatment group size (57 participants)