Methods	RCT, DB single oral and multiple oral dose, 3 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, 90 mins then hourly up to 12 h
Participants	Impacted third molar extraction Mean age 22 years N = 174 M = 75, F = 99
Interventions	Celecoxib 200 mg, n = 74 Ibuprofen liquigel 400 mg, n = 74 Placebo, n = 26
Outcomes	PI: 4-point scale PR: 5-point scale PGE: std 5-point scale (patients reporting “very good” or “excellent”) Time to use of rescue medication Number of participants using rescue medication Number of participants reporting any adverse event and serious adverse events Number of participants withdrawing due to adverse event
Notes	Oxford Quality Score: R2, DB2, W1 Participants asked to refrain from rescue medication for 1 h
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	“computer-generated allocation schedule”
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Low risk	Double-dummy method. “The appearance, presentation and labelling of the placebo formulations were identical to those of the corresponding active drugs”
Incomplete outcome data (attrition bias) All outcomes	Low risk	Participants accounted for; analysis appropriate for relevant time interval
Other bias	High risk	Small treatment group size (74 active, 26 placebo participants)