Methods	RCT, DB, double-dummy, single oral dose, 3 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, 90 mins then hourly up to 12 h, and at 24 h
Participants	Impacted third molar extraction Mean age 23 years N = 364 M = 133, F = 231
Interventions	Celecoxib 400 mg, n = 156 Lumiracoxib 400 mg, n = 156 Placebo, n = 52
Outcomes	PI: std 4-point scale PR: std 5-point scale Time to use of rescue medication Number of participants using rescue medication Number of participants reporting any adverse event and serious adverse events Number of participants withdrawing due to adverse event
Notes	Oxford Quality Score: R2, DB1, W1 Participants permitted to use rescue medication at any time
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer-generated
Allocation concealment (selection bias)	Low risk	Remote, automated allocation to randomisation numbers
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	Participants accounted for; analysis appropriate for relevant time interval
Other bias	Unclear risk	Small treatment group size (156 active, 52 placebo participants)