Methods	RCT, DB, double-dummy, single oral dose, 4 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, 90 mins then hourly up to 12 h, and at 24 h
Participants	Impacted third molar extraction Mean age 22 years N = 355 M = 112, F = 243
Interventions	Celecoxib 200 mg, n = 101 Lumiracoxib 400 mg, n = 101 Rofecoxib 50 mg, n = 102 Placebo, n = 51
Outcomes	PI: std 4-point scale PR: std 5-point scale PGE: std 5-point scale Time to use of rescue medication Number of participants using rescue medication
Notes	Oxford Quality Score: R1, DB2, W1 Participants asked to refrain from rescue medication for 1 h
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Low risk	Double-dummy method. Placebo capsules and tablets matching corresponding active treatments
Incomplete outcome data (attrition bias) All outcomes	Low risk	Participants accounted for; analysis appropriate for relevant time interval
Other bias	Unclear risk	Small treatment group size (100 to 101 active, 51 placebo participants)