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. 2014 Sep 15;25(18):2761–2773. doi: 10.1091/mbc.E14-05-0966

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© 2014 Britigan et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 9: — Partial knockdown of Aurora B to near wild-type levels rescues mitotic defects in ARF^−/− cells. (A) Immunoblot demonstrating partial knockdown of Aurora B in ARF^−/− primary MEFs to levels similar to those found in wild-type MEFs. Tubulin is shown as a loading control. (B) Partial knockdown of Aurora B rescues the mitotic checkpoint defect in ARF^−/− cells. n > 250 cells from each of three independent experiments. (C) Partial depletion of Aurora B by siRNA rescues the chromosome alignment defect in ARF^−/− cells. n > 50 cells with visible metaphase plates from each of three independent experiments. (D) Knockdown of Aurora B by siRNA to near-wild-type levels in ARF^−/− cells partially rescues the occurrence of lagging chromosomes. n > 100 anaphases and telophases from each of three independent experiments. *p < 0.05.