. 2014 Aug 15;7(8):1967–1978.

Table 1.

Characteristics of studies included in the meta-analysis

Author, Year	Cases	Age¹	EGFR		Gender		Smoking		Histology		TNM stage		Detection

			M¹	W	M²	F	Y	N	ADC	NADC	I	II/III/IV	Sample	Method
Qin B, 2005 [23]	41	NA	10	31	30	11	21	20	17	24	NA	NA	FFPE	SE
Xu J, 2011 [24]	861	58	353	508	493	368	411	439	667	194	NA	NA	FFPE	SE
An S, 2012 [25]	524	59.3	147	377	361	163	232	292	354	170	143	381	SFILN	SE
Li Y, 2013 [26]	208	NA	51	157	147	61	130	78	95	113	49	159	FFPE	SE
Jing C, 2013 [27]	120	62	48	72	69	51	NA	NA	70	50	NA	NA	FFPE	HRM
Liu Y, 2013 [16]	251	NA	140	111	138	113	NA	NA	193	58	NA	NA	FFPE	SE
Zhang Y, 2013 [28]	99	NA	33	66	68	31	43	56	54	45	16	83	FFPE	ARMS
Lai Y, 2013 [14]	697	55.3	235	462	476	221	366	331	293	404	215	482	Fresh tissues	ARMS
Zhang J, 2008 [29]	82	61	42	40	48	34	40	42	59	23	44	38	FFPE	ARMS
Liang Z, 2008 [30]	290	58	121	169	145	145	NA	NA	244	46	NA	NA	FFPE	ARMS
Yin X, 2010 [31]	107	61	30	77	82	25	60	47	52	55	44	63	FFPE	SE
Feng Q, 2011 [32]	309	59.7	105	204	184	125	132	127	201	99	NA	NA	FFPE	SE
Sun M, 2011 [33]	443	57	189	254	243	200	NA	NA	346	97	NA	NA	FFPE	SE
Zhang J, 2011 [34]	454	59	219	235	256	198	279	175	340	114	NA	NA	FFPE	SE
Wang L, 2011 [35]	184	58.5	69	115	106	78	79	105	135	49	NA	NA	FFPE	BPSP
Gao J, 2012 [36]	120	65	44	76	77	43	60	60	93	27	NA	NA	FFPE	ARMS
Sun L, 2013 [37]	301	59	99	202	174	127	173	128	188	113	NA	NA	FFPE	SE
Zhang X, 2005 [38]	76	62.5	31	45	41	35	NA	NA	51	25	NA	NA	FFPE	SE
Wu Y, 2005 [15]	142	60	42	100	98	44	84	58	90	52	60	82	FFPE	SE
Zhang L, 2005 [39]	52	58	10	42	39	13	33	19	28	24	NA	NA	FFPE	SE
Zhou C, 2005 [40]	81	62	21	60	52	29	41	40	38	43	34	47	FFPE	SE
Total	5442	—	2039	3403	3327	2115	2184	2017	3608	1825	605	1335	—	—

Abbreviations: Age¹: median age; M¹: mutant type EGFR; W: wild type EGFR; M²: male; F: female; Y: smoker; N: non-smoker; ADC: adenocarcinoma; NADC: non-adenocarcinoma NSCLC; NA: not available; FFPE: formalin-fixed, paraffin-embedded tissues; SFILN: snap-frozen tissues in liquid nitrogen; SE: sequencing; HRM: high resolution melting analysis; ARMS: amplification mutation refractory system; BPSP: bi-loop probe and specific primer quantitative PCR.