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. Author manuscript; available in PMC: 2014 Sep 11.
Published in final edited form as: Am J Physiol Lung Cell Mol Physiol. 2006 Aug 4;291(6):L1256–L1266. doi: 10.1152/ajplung.00079.2006

Figure 7. Effect of CD8+ T cells on lung function during PcP in CD4-depleted IRD mice.

Figure 7

Pulmonary function testing was performed on Pneumocystis carinii-infected IRD mice in the absence of CD4+ T cells. During weeks 2 and 4 post-immune reconstitution, lung compliance (Panel A), and resistance (Panel B) measurements were taken on CD4-depleted (closed circles) and CD4/CD8-depleted (open circles) IRD mice. Pneumocystis carinii-infected mice that were not immune reconstituted served as controls (closed triangles).. P. carinii burden for the CD4-depleted mice are shown in Panel C. The results were pooled data from three independent experiments, and each data point is the arithmetic mean ± 1 SEM (n= 8-11 mice for each IRD group at each time point; n= 3 mice at each time point for non-reconstituted mice). *p<0.05 as compared to non-reconstituted, infected mice. **p<0.05 as compared to both non-reconstituted and CD4/CD8-depleted IRD mice.