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Sivelestat and aquaporumab reduce NMO-IgG–mediated placental damage. (A) Placentas (H&E, C5b-9 immunostain, AQP4 immunostain) after i.p. injection of NMO-IgG53 plus Chu (n = 3), NMO-IgG53 plus Chu plus sivelestat (+S, n = 3) or NMO-IgG53 plus Chu plus aquaporumab (+A, n = 3). (B) Percentage of placentas with neutrophil infiltration and C5b-9 deposits and percentage of dead fetuses per pregnant mouse. Scale bars, 30 μm [(A) H&E right, C5b-9, AQP4], 300 μm [(A) H&E left]. *p < 0.01.
