Table 1.
Nomenclature of nuclear receptors
| Subfamily official name (class) | NRNC group | Member trivial name | Official name | Abbreviation | Ligand |
| NR0 (domain-depleted receptors) | B [DAX-like receptors (DAX, SHP)] | Dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 | NR0B1 | DAX-1 | Orphan |
| NR1 (TR/RAR/PPAR/VDR-like receptors) | A (thyroid hormone receptors) | Short heterodimer partner | NR0B2 | SHP | Orphan |
| Thyroid hormone receptor α | NR1A1 | TRα | GC-1, thyroid hormone | ||
| B (retinoic acid receptors) | Thyroid hormone receptor β | NR1A2 | TRβ | GC-1, thyroid hormone | |
| Retinoic acid receptor α | NR1B1 | RARα | Am 580, all-trans-Retinoic acid, Arotinoid acid | ||
| Retinoic acid receptor β | NR1B2 | RARβ | Am 580, all-trans-Retinoic acid, Arotinoid acid | ||
| C (peroxisome proliferator activated receptors) | Retinoic acid receptor γ | NR1B3 | RARγ | Am 580, all-trans-Retinoic acid, Arotinoid acid | |
| Peroxisome proliferator-activated receptor α | NR1C1 | PPARα | GW409544, GW7647, GW6471, Pirinixic acid, Palmitic acid, Leukotriene B4 | ||
| Peroxisome proliferator-activated receptor β | NR1C2 | PPARβ/δ | Eicosapentaenoic acid, GW0742 | ||
| Peroxisome proliferator-activated Receptor γ | NR1C3 | PPARγ | Rosiglitazone, GW1929, GW9662, GW409544, GW7647, 15-Deoxy-∆-12,14-prostaglandin, 15-Deoxy-∆-12,14-PGJ2 | ||
| D [Rev-Erb (NRD, E75)]F (RAR-related orphan receptors (ROR, HR3) | Rev-erbα | NR1D1 | Rev-erbα | Orphan | |
| NR1D2 | Rev-erbβ | Orphan | |||
| Retinoic acid receptor-related orphan receptor α | NR1F1 | RORα | Melatonin, CGP 52608 | ||
| Retinoic acid receptor-related orphan receptor β | NR1F2 | RORβ | Melatonin, CGP 52608 | ||
| Retinoic acid receptor-related orphan receptor γ | NR1F3 | RORγ | Melatonin,CGP52608 | ||
| Liver X receptor β | NR1H2 | LXRβ | GW3969, T0901317, oxysterols | ||
| H (ecdysone-like receptors) | Liver X receptor α | NR1H3 | LXRα | GW3969, T0901317, oxysterols | |
| Farnesoid X receptor α | NR1H4 | FXRα | GW4064, bile acid chenodeoxycholic acid | ||
| I (vitamin D3-like receptors) | Vitamin D3 receptor | NR1I1 | VDR | 1,25-dihydroxyvitamin D3 | |
| Pregnane X receptor | NR1I2 | PXR | Hyperforin, SR12813, rifampicin, pregnenolone carbonitrile, T0901317, 24(S),25-epoxycholesterol, butamben | ||
| Constitutive androstane receptor | NR1I3 | CAR | Androstanol, CITCO, phenobarbital, ATE | ||
| NR2 (HNF4/RXR/TLL/COUP-like receptors) | A (hepatocyte nuclear factor 4) | Hepatocyte nuclear factor 4 α | NR2A1 | HNF4α | Palmitoyl coenzyme A |
| Hepatocyte nuclear factor 4 γ | NR2A2 | HNF4γ | Orphan | ||
| B (retinoid X receptors) | Retinoid x receptor α | NR2B1 | RXRα | LGD 100268, GW0791, 9-retinoic acid | |
| Retinoid x receptor β | NR2B2 | RXRβ | LGD 100268 | ||
| Retinoid x receptor γ | NR2B3 | RXRγ | LGD 100268 | ||
| Testis receptor | NR2C1 | TR2 | Orphan | ||
| E (tailless-like receptors) | NR2C2 | TR4 | Orphan | ||
| Tailless | NR2E2 | TLL | Orphan | ||
| Photoreceptor-specific nuclear receptor | NR2E3 | PNR | Orphan | ||
| F [COUP-TF-like receptors (COUP-TF, SVP, EAR2)] | Chicken ovalbumin upstream promoter transcription factor IChicken ovalbumin upstream promoter transcription factor II | NR2F1 | COUP-TFI | Orphan | |
| NR2F2 | COUP-TFII | Orphan | |||
| ErbA2-related gene-2 | NR2F6 | EAR2 | Orphan | ||
| NR3 (ER/ERR/GR/MR/PR/AR) | A | Estrogen receptor | NR3A1 | Erα | Fulvestrant, 17β-estradiol, 4-hydroxytamoxifen, Raloxifene |
| NR3A2 | Erβ | Fulvestrant, 17β-estradiol, 4-hydroxytamoxifen, Raloxifene | |||
| B | Estrogen receptor-related receptor | NR3B1 | ERRα | Orphan | |
| NR3B2 | ERRβ | GSK4716, Diethylstilbestrol | |||
| NR3B3 | ERRγ | GSK4716, 4-hydroxytamoxifen | |||
| C | Glucocorticoid receptor | NR3C1 | GR | Dexamethasone, hydrocortisone, RU486 | |
| Mineralocorticoid receptor | NR3C2 | MR | Spironolactone, aldosterone, RU486 | ||
| Progesteron receptor | NR3C3 | PR | R5020, progesterone, RU486 | ||
| Androgen receptor | NR3C4 | AR | Dihydrotestosterone, RU486, Bicalutamide, R1881 | ||
| NR4 (NGFIB-like receptors ) | A [nerve growth factor IB-like receptors (NGFIB, NURR, NOR, HR38, CNR-8)] | Growth factor-inducible immediate early gene Nur77 | NR4A1 | Nur77 | Orphan |
| Nur-related protein 1 | NR4A2 | NURR1 | Orphan | ||
| Neuron-derived orphan receptor 1 | NR4A3 | NOR1 | Orphan | ||
| NR5 (FTZ-F1/SF1-like receptors) | A [fushi tarazu F1-like receptors (SF1, FTF, FTZ-F1)] | Steroidogenic factor-1/ELP | NR5A1 | SF1 | Orphan |
| Liver receptor homolog 1 | NR5A2 | LRH-1 | Orphan | ||
| NR6 (GCNF) | A (germ cell nuclear factor) | Germ cell nuclear factor 1 | NR6A1 | GCNF1 | Orphan |
PPAR: Peroxisome proliferator-activated receptor; PDAC: Pancreatic ductal carcinoma; TZD: Thiazolidinediones; IFN: Interferon; RAR: Retinoic acid receptor; RXR: Retinoid X receptor; AR: Androgen receptor; ER: Estrogen receptor; LHR-1: Liver receptor homologue-1 receptor; COUP-TFII: Chicken ovalbumin upstream promoter transcription factor II.