Table 5.
KEGG pathway analysis of 12 miRNAs included in the UDB using DIANA-mirpath [ [25]]
| KEGG.pathway | p.value | # of genes | # of miRNAs | |
|---|---|---|---|---|
| 1 | Prion diseases | 0.00e+00 | 6 | 2 |
| 2 | Pathways in cancer | 3.00e-13 | 39 | 6 |
| 3 | PI3K-Akt signaling pathway ∗ | 1.07e-11 | 43 | 4 |
| 4 | TGF-beta signaling pathway ∗ | 5.98e-10 | 14 | 4 |
| 5 | Viral carcinogenesis | 1.56e-09 | 27 | 5 |
| 6 | Ribosome | 6.04e-09 | 22 | 1 |
| 7 | Small cell lung cancer | 6.33e-09 | 17 | 5 |
| 8 | Colorectal cancer | 1.02e-08 | 9 | 6 |
| 9 | Ribosome biogenesis | 2.02e-08 | 20 | 1 |
| in eukaryotes | ||||
| 10 | p53 signaling pathway ∗ | 6.75e-08 | 16 | 5 |
| 11 | RNA transport | 1.19e-07 | 28 | 1 |
| 12 | Cell cycle ∗ | 1.56e-07 | 22 | 3 |
| 13 | Pancreatic cancer | 2.75e-07 | 11 | 5 |
| 14 | Hepatitis B | 1.17e-06 | 12 | 5 |
| 15 | Prostate cancer | 4.64e-06 | 16 | 5 |
| 16 | Bladder cancer | 6.94e-06 | 7 | 4 |
| 17 | Chronic myeloid leukemia | 2.01e-05 | 8 | 4 |
| 18 | Measles | 1.28e-04 | 19 | 5 |
| 19 | Protein export | 3.29e-04 | 9 | 1 |
| 20 | Non-small cell lung cancer | 3.69e-04 | 6 | 5 |
| 21 | HTLV-I infection | 1.43e-03 | 11 | 3 |
| 22 | Glioma | 1.46e-03 | 6 | 3 |
| 23 | Melanoma | 1.71e-03 | 7 | 5 |
| 24 | Transcriptional misregulation | 1.22e-02 | 9 | 3 |
| in cancer | ||||
| 25 | Oocyte meiosis | 1.36e-02 | 14 | 1 |
| 26 | Focal adhesion ∗ | 1.50e-02 | 8 | 3 |
| 27 | Epstein-Barr virus infection | 2.45e-02 | 19 | 3 |
Bold faces: tumors/cancers, Bold italic: other diseases, Italic: tumors/cancers related, *parts of “Pathways in cancer”, and surrounded by blue rectangular in Figure 3.