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. 1971 Apr;3(4):559–561. doi: 10.1128/iai.3.4.559-561.1971

Latent Syphilis: Immunoglobulins Reactive in Immunofluorescence and Other Serological Tests

A J Julian 1, L C Logan 1, L C Norins 1, A T Scotti 1
PMCID: PMC416196  PMID: 16558017

Abstract

Study of sera from 69 patients with untreated or inadequately treated latent syphilis revealed that immunoglobulin (Ig)G antibodies made up the bulk of the fluorescent treponemal antibody-absorption (FTA-ABS)-test reactivity found in the sera. IgM and IgA antibodies also contributed in some cases. Venereal Disease Research Laboratory slide-test reactivity was found in both 19 and 7S serum fractions, whereas Treponema pallidum immobilization-test reactivity was found mainly in the 7S fraction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Deacon W. E., Lucas J. B., Price E. V. Fluorescent treponemal antibody-absorption (FTA-ABS) test for syphilis. JAMA. 1966 Nov 7;198(6):624–628. [PubMed] [Google Scholar]
  2. Hunter E. F., Norins L. C., Falcone V. H., Stout G. W. The fluorescent treponemal antibody-absorption (FTA-ABS) test. Development, use and present status. Bull World Health Organ. 1968;39(6):873–881. [PMC free article] [PubMed] [Google Scholar]
  3. Julian A. J., Logan L. C., Norins L. C. Early syphilis: immunoglobulins reactive in immunofluorescence and other serologic tests. J Immunol. 1969 May;102(5):1250–1259. [PubMed] [Google Scholar]
  4. Logan L. C., Norins L. C., Atwood W. G., Miller J. L. Treated late syphilis: immunoglobulin class of antibodies reactive with Treponema pallidum. J Invest Dermatol. 1969 Oct;53(4):300–301. doi: 10.1038/jid.1969.151. [DOI] [PubMed] [Google Scholar]
  5. ROCKWELL D. H., YOBS A. R., MOORE M. B., Jr THE TUSKEGEE STUDY OF UNTREATED SYPHILIS; THE 30TH YEAR OF OBSERVATION. Arch Intern Med. 1964 Dec;114:792–798. doi: 10.1001/archinte.1964.03860120104011. [DOI] [PubMed] [Google Scholar]
  6. Tringali G. R., Julian A. J., Halbert W. M. Effect of 2-mercaptoethanol treatment on anticardiolipin reactivity in sera from syphilitics and false positive reactors. Br J Vener Dis. 1969 Sep;45(3):202–204. doi: 10.1136/sti.45.3.202. [DOI] [PMC free article] [PubMed] [Google Scholar]

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