Table 2.
Associations Between Parasite Genotypes and Clinical Presentations
| Polymorphism | Febrile Subjects (%) | Asymptomatic Subjects (%) | Unadjusted Results |
Adjusted Resultsa |
||
|---|---|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |||
| K76T | ||||||
| Mutant | 219 (91.3) | 211 (98.6) | Reference | … | Reference | … |
| Mixed | 21 (8.8) | 3 (1.4) | 6.20 (1.97–19.5) | .002 | 4.41 (1.28–15.1) | .02 |
| N86Y | ||||||
| Mutant | 40 (16.5) | 64 (27.9) | Reference | … | Reference | … |
| Mixed | 88 (36.7) | 118 (51.5) | 1.16 (.55–2.44) | .69 | 1.02 (.43–2.40) | .97 |
| Wild type | 115 (47.9) | 47 (20.5) | 3.67 (1.87–7.23) | <.001 | 4.08 (2.01–8.31) | <.001 |
| D1246Y | ||||||
| Mutant | 72 (34.8) | 86 (37.2) | Reference | … | Reference | … |
| Mixed | 111 (53.6) | 138 (59.7) | 0.97 (.58–1.62) | .91 | 0.91 (.52–1.59) | .73 |
| Wild type | 24 (11.6) | 7 (3.0) | 4.13 (1.81–9.43) | .001 | 4.90 (1.52–15.8) | .008 |
Abbreviations: CI, confidence interval; OR, odds ratio.
a Adjusted for age, complexity of infection, parasite density, and clustering.