TABLE 2.
Bupropion and hydroxybupropion 6-hour concentrations (ng/ml) and metabolic ratio across sex/ethnicity cohorts (N = 100)
Values are expressed as geometric means (±95% confidence intervals). As statistical analysis is more appropriately performed using analysis of covariance (ANCOVA) on log-transformed data, these tabulations are provided only for descriptive purposes. Each group had 25 patients.
| Unadjusted |
Dose-Adjusteda |
||||
|---|---|---|---|---|---|
| BU | HB | BU | HB | HB/BU | |
| CAM | 66.67 (57.99–76.65) | 260.95 (206.40–329.92) | 76.10 (66.19–87.50) | 297.88 (235.44–376.89) | 3.92 (3.08, 5.00) |
| CAW | 83.62 (73.14–95.60) | 354.77 (317.59–396.30) | 71.56 (63.82–80.25) | 303.61 (271.80–339.14) | 4.24 (3.62, 4.97) |
| AAW | 66.13 (53.67–81.49) | 258.55 (191.14–349.73) | 75.92 (61.43–93.84) | 296.81 (224.46–392.49) | 3.97 (2.80, 5.64) |
| HAW | 55.60 (43.89–70.44) | 330.90 (282.86–387.10) | 49.74 (38.48–64.31) | 296.05 (256.49–341.71) | 6.01 (4.60, 7.85) |
AAW, African-American women; BU, bupropion; CAM, Caucasian-American men; CAW, Caucasian-American women; HAW, Hispanic-American women; HB, hydroxybupropion.
a
Prior to computation of the geometric mean, plasma concentrations were adjusted to correspond to a standard dose for a 70-kg weight individual.